Researchers in Japan analyzed genetic and clinical information of 700,000 individuals from biobanks in the UK, Finland and Japan.

According to the study they found that high blood pressure and obesity were the two strongest risk factors that reduced lifespan of a human.

https://resou.osaka-u.ac.jp/en/research/2020/20200324_3

"The researchers found that high blood pressure and obesity were the two strongest risk factors that reduced lifespan of the current generation. Interestingly, while high blood pressure decreased lifespan across all populations the researchers investigated, obesity significantly reduced lifespan in individuals with European ancestry, suggesting that the Japanese population was somehow protected from the detrimental effects obesity has on lifespan."

“These are striking results that show how genetics can be used to predict health risks,” says Okada. “Our findings could offer an approach to utilize genetic information to seek out health risk factors with the goal of providing targeted lifestyle changes and medical treatment. Ultimately, these approaches would be expected to improve the health of the overall population.”